The whole event will take place in the Zhuhai Dehan Hotel (Guo Cui, 4/F). Final program of the conference can be found below.
Monday, August 22nd 2016 | |
15:00 – 19:00 | Participant registration / Poster mounting |
19:30 – | Welcome party – Dehan hotel |
Tuesday, August 23th 2016 | |
08:00 – 08:30 | Participant registration / Poster mounting |
08:30 – 08:45 | Opening ceremony |
Session 1. Recent advances in the physico-chemical/activity profiling of drug substances | |
08:45 - 9:30 | Jin Li, Hitgen Ltd., China Finding needles in very large haystacks: DNA-encoded libraries (DELs) for lead generation |
9:30 – 10:15 | Godefridus J Peters, VU University Medical Center, The Netherlands Role of physico-chemical and ADME properties in cancer drug development |
10:15 – 10:45 | Coffee break / Poster session |
10:45 – 11:30 | Kwok-Yin Wong, The Hong Kong Polytechnic University, China Development of Fluorescent Biosensors for Screening of Inhibitors of Some Bacterial Enzymes |
11:30 – 12:15 | Wei Gao, Tonglei Li, Purdue University, USA Development of Drug Nanocrystals for Theranostics |
12:15 – 12:40 | Caroline Alvebratt, Erik Petersson, Maria Strömme, Christel A.S. Bergström, Uppsala University, Sweden A small scale method to determine release rate from complex carrier-mediated systems |
Lunch | |
Session 2. Recent advances in solid state characterization | |
14:30 – 15:15 | Rolf Hilfiker, Solvias AG, Switerland Impact of Polymorphism on the Development and Manufacturing of Pharmaceuticals |
15:15 – 16:00 | Alex Avdeef, in-ADME Research, USA Cocrystal Solubility-pH Data Analysis using pDISOL-X (with Automatic Equilibrium Equation Generation) |
16:00 – 16:20 | Shichao Du, Yan Wang, Jingkang Wang, Junbo Gong, Tianjin University, China Two Novel Cocrystals with Improved Solubility and In Situ Monitoring of Cocrystallization of Lamotrigine |
16:20 – 16:50 | Coffee break / Poster session |
16:50 – 17:35 | Elena Boldyreva, Novosibirsk state university, Russia Drugs as materials: processing, structure, properties |
17:35 – 18:05 | Marzena Rams-Baron, Żaneta Wojnarowska, Mateusz Dulski, Patryk Włodarczyk, Marian Paluch, University of Silesia, Poland The importance of proton transfer in amorphous active pharmaceutical ingredients |
18:05 – 18:30 | Khadijah Edueng; Denny Mahlin; Christel Bergström, Uppsala University, Sweden Mechanism-based Selection of Stabilization Strategy for Amorphous Formulation |
19:30 - | Conference dinner / Dehan hotel |
Wednesday, August 24th 2016 | |
Session 3. Recent advances in drug discovery | |
08:30 – 09:15 | Hong Wan, Shanghai Hengrui Pharmaceutical CO., LTD, China Discovery and Development of Pyrotinib: a Novel Irreversible EGFR/HER2 Dual Tyrosine Kinase Inhibitor with Favorable Safety Profiles for the Treatment of Breast Cancer |
09:15 – 09:45 | Lihua Tan, Cailan Li, Hanbin Chen, Zhizhun Mo, Jiangtao Zhou, Yuhong Liu, Zhilin Ma, Yuyao Xu, Xiaobo Yang, and Jianhui Xie, Ziren Su, Guangzhou University of Chinese Medicine, China Epiberberine, a natural protoberberine alkaloid, inhibit urease of Helicobacter pylori and jack bean via binding to the sulfhydryl groups |
09:45 – 10:15 | Wen Zhang, Xiaohui Hu, Shao-Lin Zhang, Kin Yip Tam, University of Macau, Macau Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effects |
10:15 – 10:45 | Coffee break / Poster session |
10:45 – 11:30 | Tao Chen, Bo Jiang, Yuan Xu, Feng Zhi, Yiling Yang, Ying Xia, The University of Texas McGovern Medical School, USA A Potential Target for Parkinsonism Treatment |
11:30 – 12:15 | Wen-Ying Liao, Chih-Chuang Liaw, Chien-Shu Chen, Sheng-Chu Kuo, Yuan-Chao Huang, and Chia-Ning Shen, Genomis Research Center, Academia Sinica, Taiwan Excessive porphyrin production induced by cyclohexylmethyl flavonoids suppresses self-renewal propagation of breast cancer stem cells |
12:15 - 12:40 | Li Yang, Zhongyan Wang, Huiling Zhang, Wei Xu, Shuxing Zheng, Haiyong Zhang, Yin Tian, Chong Qing University of Posts and Telecommunications, China Predictors for drug effects with Alzheimer’s disease: shed new light from EEG parameters to brain connectomics |
Lunch | |
Session 4. Recent advances in computational methods/modeling, biophysical and analytical techniques of importance in medicinal chemistry and pharmaceutical research | |
14:30 – 15:15 | Alex Avdeef, in-ADME Research, USA Data Mining for Equilibrium Solubility of Ionizable Druglike Molecules |
15:15 – 16:00 | Klara Valko, Bio-Mimetic Chromatography, UK How to optimize the physicochemical and biomimetic properties of putative drug molecules? |
16:00 – 16:30 | Mare Oja, Uko Maran, University of Tartu, Estonia Comparison and modelling of experimental and calculated distribution coefficient (logD) values at various pH-s |
16:30 – 17:00 | Coffee break / Poster session |
17:00 – 17:35 | Muhammad Arba, Rahmad Sutrisna, Ruslin, Universitas Halu Oleo, Indonesia Quantitative structure activity relationship (QSAR) analysis of Indirubin derivatives as cyclin dependent kinase 5 (CDK5) inhibitor |
17:35 – 18:10 | Ruslin, Rahmad Sutrisna, Muhammad Arba, Universitas Halu Oleo, Indonesia Design and molecular docking study of novel Indirubin derivatives as inhibitor of cyclin dependent kinase 5 (CDK5) |
18:10 - 18:30 | Poster dismounting |
Thursday, August 25th 2016 | |
Session 5. Recent advances in drug development | |
09:00 – 09:45 | Abu T.M. Serajuddin, St. John’s University, USA Strategies for the development of liquid, semisolid and solid lipid-based drug delivery systems |
09:45 – 10:30 | Marian Paluch and Justyna Knapik, University of Silesia, Poland Study on effective methods for stabilizing the amorphous forms of of anti-cholesterol drug: Ezetimibe |
10:30 – 11:00 | Coffee break |
11:00 – 11:45 | Kiyhiko Sugano, Toho University, Japan Theoretical investigation on bioequivalence and biowaiver scheme |
11:45 – 12:30 | Shun Ming Yuen, Jie Ye, Gillian Murphy, Ruiyu Xie and Hang Fai Kwok, University of Macau, Macau Anti-Tumour Effects of a Human & Mouse Cross-Reactive’ Anti-TACE Antibody in a Pancreatic Cancer Model In Vivo |
12:30 | Conference closing |
14:00 | Optional excursion: Zhuhai sightseeing tour and dinner |
Friday, August 26th 2016 | |
08:30 – 18:00 | Post-conference course: Short introduction in drug development |