Sunday, September 20th
15:00 – 19:30
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Participant registration
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20:00 –
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Welcome party
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Monday, September 21st
08:00 – 09:00
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Poster mounting
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09:00 – 09:15
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Opening ceremony
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09:15 – 10:00
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Peter Krajcsi, Solvo Biotechnology, Hungary
Models and methods to study drug transport accross barriers
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10:00 – 10:45
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Klara Valko, GSK, UK
Physicochemical and biomimetic properties to guide lead optimization to improve in vivo efficacy
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10:45 – 11:15
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Coffee break
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11:15 – 11:50
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Konstantin Tsinman, pION, USA
Studying Interplay of Dissolution, Solubility and Permeability in Formulation Development using In Situ Concentration Monitoring
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11:50 – 12:25
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Antonio Llinàs, Rebeca Ruiz, John Comer, Sirius Analytical Ltd., UK
The measurement of physicochemical properties of orally inhaled drugs at 37 °C in Simulated Lung Fluid – methods and formulations
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12:25 – 13:00
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Martí Rosés, Elisabet Fuguet, Joan Marc Cabot, University of Barcelona, Spain
Determination of the acidity of poorly water-soluble drugs by the Internal Standard - Capillary Electrophoresis method
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Lunch | |
15:00 – 15:45
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Abu Serajuddin, St. John’s University, USA
Strategies for the development of liquid, semisolid and solid lipid-based drug delivery systems
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15:45 – 16:30
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Christos Reppas, University of Athens, Greece
Predictive in vitro tests for locally acting oral medicinal products?
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16:30 – 17:00
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Coffee break
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17:00 – 17:35 |
Josef Jampilek, Aneta Cernikova, Katarina Tabiova, Pavel Bobal, University of Veterinary and Pharmaceutical Sciences, Czech Republic In vitro evaluation of 8- substituted 6,9-diazaspiro[4.5]decan-7,10-diones as skin permeation modifiers
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17:35 – 18:10
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Jasmina Lovrić, University of Zagreb, Croatia
Early biopharmaceutical characterization to predict eye-related bioavailability
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18:10 – 18:30
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Vesna S. Živanović, Miloš P. Pešić, Viola Horváth, János Madarász, Ilija N. Cvijetić, Gordana V. Popović, Tatjana Ž. Verbić, Alex Avdeef, University of Belgrade, Serbia
Terfenadine solubility studies
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Monday, September 21st - Speical solubility session
20:30 – 20:50
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Alex Avdeef, in- ADME Research, USA
Data Mining for Equilibrium (Non-Amorphous) Solubility of Druglike Molecules
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20:50 – 21:10
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Krisztina Takács-Novák, Gergely Völgyi,Semmelweis University, Hungary
Best practices for saturation shake-flask measurements of thermodynamic solubility
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21:00 – 21:30
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Elisabet Fuguet, Elham Shoghi, Elisabeth Bosch, Clara Ràfols,University of Barcelona, Spain
Solubility–pH profiles of some drugs determined by the shake-flask method
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21:30 – 21:50
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Antonio Llinàs, AstraZeneca R&D, Sweden
The solubility challenge
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Tuesday, September 22nd
09:00 – 09:45
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Hong Wan, Shanghai Hengrui Pharmaceutical, China
Antibody-drug conjugate (ADC) drug development from ADME perspectives
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09:45 – 10:20
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Ta-Chau Chang, National Taiwan University, Taiwan
Molecular imaging of fluorescent ligand-DNA interaction in live cells for guiding the development of anti-cancer agents
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10:20 – 10:50
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Csaba Hetényi, Norbert Jeszenői, Mónika Bálint, David van der Spoel, István Horváth, Hungarian Academy of Sciences, Hungary
Dynamic prediction of hydration structures of biomolecular complexes
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10:50 – 11:15
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Coffee break
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11:15 – 11:50 |
Godefridus J. Peters, R.J. Honeywell, VU University Medical Center, The Netherlands The role of uptake, cellular or tissue distribution, and the target on the efficacy of tyrosine kinase inhibitors
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11:50 – 12:25
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Kin Tam, Wei Zhou, Ken Yung, Ricky Wong, Hung Wing Li, Unviersity of Macau, Macau
Permeability assessment and pharmacokinetics of some β-amyloid aggregation inhibitors for the treatment of Alzheimer’s disease
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12:25 – 13:00
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Yin Tian, Zechao Ding, Zhongyan Wang, Huiling Zhang, ChongQing University of Posts and Telecommunications, China
The predictors of drug effects on Alzheimer’s disease: shed new light from EEG parameters to brain connectomics
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Lunch | |
15:00 – 15:40
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Ernest Meštrović, Pliva Croatia Ltd., Croatia
The role of Material Science in the Research and Development of Drug Substance and Drug Product
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15:40 – 16:20
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Elena Boldyreva, Novosibirsk State University, Russia
Non-ambient conditions in drug forms discovery and development
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16:20 – 16:40
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Marzena Rams-Baron, Zaneta Wojnarowska, Mateusz Dulski, Katarzyna Grzybowska, Justyna Knapik, Marian Paluch, University of Silesia, Poland
The impact of molecular mobility and molecular interaction patterns on physical stability of amorphous anti-inflammatory agents
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16:40 – 17:00
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Coffee break
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17:00 – 17:45
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Rolf Hilfiker, Solvias AG, Switzerland
Quantification of Amorphous Content in Drug Substance and Drug Product
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17:45 – 18:15
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Biljana Janković, Stane Srčič, University of Ljubljana, Slovenia
Quantitative mechanical measurements at the nano-scale for the crystalline pharmaceutical ingredients
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18:15 – 18:30
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Marian Paluch, Karolina Adrjanowicz, University of Silesia, Poland
Toward Better Understanding of Crystallization of Amorphous Drugs under Compression: Isochronal Crystallization Kinetics Approach
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18:30 – 18:45
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Tamás Sovány, Barbara Sipos, Zoltán Kónya, Klára Pintye-Hódi, Géza Regdon jr, University of Szeged, Hungary
Application of titanate nanotube composites for the modification of the solubility, dissolution kinetic and processability of drugs
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18:45 – 23:00
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Poster session
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Wednesday, September 23rd
08:00 – 09:00
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Poster dismounting
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09:00 – 09:45
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Uko Maran, Sulev Sild, Villu Ruusmann, Geven Piir, Alfonso T. García-Sosa, Kalev Takkis, Mare Oja, Elmar Laigna, Priit Ahte, Iiris Kahn, Andre Lomaka, University of Tartu, Estonia
QsarDB: chemo-informatics solution for preserving and efficient use of in silico physicochemical, toxicological, biochemical and human health endpoint models
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09:45 – 10:30
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Michael B. Bolger, Viera Lukacova, James M. Mullin, Ke Xu-Szeto, Simulations Plus Inc., USA
Simulation of in vitro Caco-2 Papp from Molecular Structure (Kubinyi vs. QSAR) and Estimation of Intracellular Km for Efflux Transporters
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10:30 – 11:00
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Coffee break
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11:00 – 11:35 |
Łukasz Pałkowski, Jerzy Błaszczyński, Andrzej Skrzypczak, Jan Błaszczak, Alicja Nowaczyk, Roman Słowiński, Jerzy Krysiński, Nicolaus Copernicus University, Poland Structure-activity relationship analysis of new antipseudomonal gemini-imidazolium chlorides
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11:35 – 12:10
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Mario Grassi, Samuel Golob, Fabio Pontelli, Michela Abrami, Gianluca Chiarappa, Gabriele Grassi, Beatrice Perissutti, Dario Voinovich, University of Trieste, Italy
Antibacterial drug release from a biphasic polymeric system: mathematical modelling
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12:10 – 12:40
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Ena Melvan, Antonio Starčević, Jurica Zucko, Mario Cindirić, Ivo Ugrina, Daslav Hranueli, University of Zagreb, Croatia
The importance of mathematics in proteomics sequencing
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Lunch | |
14:00 | Excursion and Conference dinner |
Thursday, September 24th - joint PCMDDD-4 and Met4pharm session
10:00 – 10:45
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Cristina Daolio, Bruker BioSpin GmbH, Germany
LC-SPE-(cryo)NMR/MS as routine analysis technique
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10:45 – 11:30
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Janez Plavec, National Institute of Chemistry, Slovenia
Exploration of tetrahelical DNA structures as dynamic drug targets by NMR
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11:30 – 12:00
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Coffee break
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12:00 – 12:45 |
Kevin Embery, AstraZeneca R&D, UK The Application of NMR within Drug Discovery: Overview and Case Studies
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12:45 – 13:30
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Tomislav Biljan, Pliva Croatia Ltd., Croatia
Fluorine NMR in pharma development: from drug substance to drug product
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13:30 | Conference closing |