IAPC-8 Program

Hotel Park, Split, Croatia, September 09-11, 2019

The speakers at IAPC conferences are eminent and worldwide known scientists who made and are still making a considerable impact in the field.

Special solubility session: State-of-the-Art Solubility Methods in Drug Development will be organzied by Alex Avdeef and Christel Bergström. The session is a continuation of the previous special sessions on solubility which took place on Red island (2015) and special cocrystal session in Zagreb (2017). Red Island session resulted in the highly attracted and downloaded solubility white paper. The Perspectives of the solubility measurements and interpretation as an introduction to the solubility session can be downloaded as a review paper published in ADMET and DMPK.

Preliminary program can be found below. Please note that changes to the program are still to be expected until the start of the conference.

 

Sunday, September 08th

15:00 – 19.30 

 Participant registration, Hotel Park

20:00 –

 Welcome party, Museum History Bar, Bačvice beach

 

All sessions will be held in Grand hall, Hotel Park

Monday, September 09th

08:00

Poster mounting

 

09:00 – 09:30       

Opening Ceremony

 

Combined Session -  Moderator: Biserka Cetina Čižmek 

 

09:30 – 10:10

Aleksandar Danilovski, Xellia Pharmaceuticals Ltd. Croatia
Beauty of non-covalent interactions - disruptive repurpusing

 

10:10 – 10:50 

 

Christos Reppas, University of Athens, Greece
The environment in the lower intestine and its impact on drug absorption

 

10:50 – 11:10

Coffee break

 

11:10 – 11:50

 

M. Abrami, P. Marizza, F. Zecchin, P. Bertoncin, D. Marson, R. Lapasin, F. de Riso, P. Posocco, G. Grassi and Mario Grassi, University of Trieste, Italy
Importance of hydrogels network characteristics on drug release kinetics

 

11:50 – 12:30

 

O. Firuzi, P.P. Che, B. El Hassouni, M. Buijs, S. Coppola, M. Löhr, N. Funel, R. Heuchel, I. Carnevale, T. Schmidt, L. Saso, Godefridus J. Peters, Elisa Giovannetti, VU University Medical Center, The Netherlands
Bioluminescent/fluorescent co-culture spheroids of primary human pancreatic cancer and stellate cells as models for chemoresistances, role of c-MET inhibitors

 

12:30 – 13:10

Kin Tam, University of Macau, China
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors

 

13:10 – 15:00

Lunch Time

 

Solubility Session - Moderators: Alex Avdeef and Christel Bergström  

 

15:00 – 15:40

 

Christel Bergström, Uppsala University, Sweden
Molecular properties of importance for drug solubility in intestinal fluids

 

15:40 – 16:20

 

Patrick Augustijns, D. Riethorst and J. Brouwers,  KU Leuven, Belgium
Solubility in the inside: gastrointestinal concentrations as driving force for absorption

 

16:20 – 16:35

Coffee break

16:35 – 17:15

 

Abu T. M. Serajuddin, St. John’s University, USA
Supersolubilization of poorly water-soluble drugs, followed by conversion into amorphous solid dispersions, by acid-base interaction

 

17:15 – 17:55

 

German Perlovich, Institute of Solution Chemistry of RAS, Russia
Poorly soluble drugs: disbalance of thermodynamic characteristics of crystal lattice and solvation

 

17:55 – 18:35

 

Kiyohiko Sugano, Ritsumeikan University, Japan
Nonsink or nonthink? Dissolution tests for supersaturable drug substances

18:35 – 20:00      

Short Break, Poster session

 

20:00 – 20:40

 

Deanna Mudie, C. Bergström and G. Amidon, Lonza Pharma & Biotech, USA
No one medium fits all. Combining drug properties and physiology to select in vivo relevant dissolution media

20:40 – 21:10

 

Zahari Vinarov, V. Katev, N. Burdzhiev, S. Tcholakova, N. Denkov, Sofia University, Bulgaria
Impact of Surfactant−Bile Interactions on the Solubility of Hydrophobic Drugs in Biorelevant Dissolution Media

21:10 – 21:30

 

Emma Hokkala, M. Agopov, C.J. Strachan, E. Järvinen, K. Semjonov, J. Yliruusi, S. Svanbäck, The Solubility Company, Helsinki, Finland
Comparison of Solubility using Non-Specific Image-Based Single-Particle Analysis (SPA) and the Gold Standard Shake-Flask Methods

21:30 – 21:50

Jernej Štukelj, S. Svanbäck, M. Agopov, K. Löbmann, C. J. Strachan, T. Rades and J. Yliruusi, University of Helsinki, Finland
Direct Measurement of Amorphous Solubility

21:50 –

Solubility session discussions, Poster session

   

 

Tuesday, September 10th

Solubility Session continuation - Moderators: Alex Avdeef and Christel Bergström  

09:00 – 09-40      

 

Sara Carlert, AstraZeneca, Gothenburg, Sweden
Industrial perspective on solubility, supersaturation and precipitation: Risks, opportunities and mechanistic understanding.

09:40 – 10:20

 

O.S. Marković, M.P. Pešić, A.V. Shah, A.T.M. Serajuddin, A. Avdeef, Tatjana Ž. Verbić, University of Belgrade, Serbia
Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates

10:20 – 11:00

 

David Palmer, University of Strathclyde, UK

TBA

11:00 – 11:15

Coffee break

11:15 – 11:55 

 

Christoph Loschen, A. Klamt, COSMOlogic GmbH, Germany
Complementing drug development with fast and accurate liquid phase thermodynamic calculations: COSMO-RS applications to cocrystals, solvates, phase diagrams

11:55 – 12:35

 

Alex Avdeef, in-ADME Research, USA
Intrinsic Solubility:  Random Forest Method Predictions based on a New Deeply-Mined and Curated Database (>6350 entries)

12:35 – 13:15

 

Alex Avdeef, in-ADME Research, USA
"Hands-On" Tutorial in the use of pDISOL-X for solubility calculations: interested attendees will be invited to install the fully-functional 30-day demo program on their laptops in the tutorial demonstration.

13:30 – 19:00

The excursion to the Krka waterfalls National park (lunch package will be provided)

20:00 -

Social dinner

 

Wednesday, September 11th

08:00

Poster dismounting

Physhem and ADMET Session - Moderators: Kin Tam and Kiyohiko Sugano

09:00 – 09:40      

 

Klara Valko, Bio-Mimetic Chromatography Ltd, UK
Application of biomimetic HPLC properties for the estimation of brain to blood distribution of drug discovery compounds including new modalities

09:40 – 10:20

 

Annete Bauer-Brandl, University of Southern Denmark, Denmark
High throughput dissolution- permeation screening: a novel tool for early formulation development

10:20 – 11:00

 

Konstantin Tsinman, pION, USA
Novel In Vitro Tools for Investigating the Absorbtion Behavior of Drug Products

11:00 – 11:20

Coffee break

11:20 – 12:00

 

Derek P. Reynolds, Reytek Consulting, UK
Application of Hunter H-bond parameters (α and β) for the description of solvents and calculation of solute solubility and partition

12:00 – 12:40

 

Josef Jampilek, A. Pokorna, P. Bobal, Comenius University in Bratislava, Slovakia
Investigation of permeation of drugs through skin using methylated piperazine-2,5-diones

12:40 – 13:10

Mare Oja, Sulev Sild, Uko Maran, University of Tartu, Estonia
Quantitative and qualitative prediction models for pH-membrane permeability profiles: improving prediction of absorption in gastrointestinal tract

13:10 – 13:30

Alejandro Fernández-Pumarega, S. Amézqueta, E. Fuguet, M. Rosés, University of Barcelona, Spain
Estimation of the octanol-water distribution coefficient through chromatographic measurements

13:30 – 15:00

Lunch

Solid state Session - Moderators: Tatjana Verbić and Mario Grassi

15:00 – 15:40

 

Elena Boldyreva, Novosibirsk State University, Russia
Physical treatment of pharmaceuticals as a method of fine-tuning their properties

15:40 – 16:20

Rolf Hilfiker, Solivas AG, Switzerland
Development of Methods to Quantify Solid Form Purity

16:20 – 17:00

David B. Turner, S. Arora, M. Jamei, Certara Ltd, UK
Exploiting Dual Solid State PBPK Tools to Assess the Bio(in)equivalence of Tacrolimus Amorphous Formulations with Various Degrees of Crystallization Arising During Storage

17:00 – 17:20

Coffee break

17:20 – 18:00

Abu T. M. Serajuddin, St. John’s University, USA
Development of HPMCAS-based Amorphous Solid Dispersion by Melt Extrusion

18:00 – 18:25

Justyna Knapik-Kowalczuk, K. Chmiel, K. Jurkiewicz, R. Jachowicz, M. Paluch, University of Silesia, Poland
Physically stable amorphous APIs – are thay ready for extrusion?

18:25 – 18:50

Lidia Elena Crica, L. Papafilippou, D. Jasim, M. Hadjidemetriou and  K. Kostarelos, University of Manchester, UK
Proteomic enrichment of urine by renal excretion of graphene oxide

18:50

Conference closing