Program

Below is the preliminary program, which is subject to change by the start of the conference.
List of poster presentations is HERE.

Sunday, September 3

Monday, September 4

18:30 - 17:00   Participant registration, University of Belgrade Rectorate building (conference venue)

19:00 - 19:45  Opening ceremony

Chairs: Tatjana Verbić and Zoran Mandić

10:00 - 10:40 O-01		Christel Bergström, Uppsala University, Sweden Virtual assessment to provide insights into drug-excipient-intestinal fluid interactions and support virtual formulation design
10:40 - 11:20 O-02		Christos Reppas, University of Athens, Greece In vitro evaluation of drug presence in the micellar phase of contents of upper small intestine: rationale, challenges, opportunities
11:20 - 11:50 O-03		Gilles Goetz, Pfizer Inc, USA Continuous Improvement in the molecular properties assessment world
11:50 - 12:20		Analysis Coffee break + poster presentations

Chair: Godefridus Peters

12:20 - 13:00 O-04		Gaia Colombo, University of Ferrara, Italy Nanotechnology enabled innovation in inhalation drug delivery
13:00 - 13:40 O-05		Miroslav Savić, University of Belgrade, Serbia Neuropharmacokinetics: the secret life of – old and novel – psychopharmacological drugs
13:40 - 15:00		Lunch break

Special session on Solubility of Multi-Component Solids (Salts and Cocrystals)
Session co-chairs: Kiyohiko Sugano and Alex Avdeef

15:30 - 16:10 O-06		Alex Avdeef, in-ADME Research, New York, USA Celebrating 40 years of the Ross electrode and 50 years of pHmax
16:10 - 16:50 O-07		Kiyohiko Sugano, Ritsumeikan University, Japan Salt disproportionation in bicarbonate buffer
16:50 - 17:30 O-08		Abu Serajuddin, St. John’s University, New York, USA Development of rapidly dissolving 3D-printed tablets for personalized medicine by applying acid-base supersolubilization (ABS) principle
17:30 - 18:00		Coffee break + poster presentations

18:00 - 18:30 O-09		Yan He, Sanofi, USA Salt selection for development - solubility & bioperformance advantages from salts made by weaker acidic counterions explained by thermodynamic equilibria
18:30 - 19:00 O-10		Tonglei Li, Purdue University, USA Solubility prediction by deep learning of quantum information
19:00 - 19:30 O-11		Sami Svanbäck, The Solubility Company Ltd. Helsinki, Finland Micro-scale solubility measurement to guide early decision making
19:30 - 20:00 O-12		Elisabet Fuguet, University of Barcelona, Spain Insights in the solubility and dissolution rate determination of cocrystals
19:30 - 19:50 O-13 WITHDRAWN		Kader Poturcu, Suleyman Demirel University, Isparta, Turkey Preparation and characterization of solid dispersion of mesalazine using anti-solvent precipitation technique
20:00 - 20:30		Open discussions

Tuesday, September 5

Chair: Christel Bergström

19:00 - 19:40 O-14		Tatjana Verbić, University of Belgrade, Serbia Revealing the story of an orphan drug: clofazimine speciation and solubilization as a function of pH
19:40 - 10:20 O-15		Annette Bauer Brandl, University of Southern Denmark, Denmark Amorphous solid dispersions: true supersaturation measured in a time-resolved manner by microdialysis
10:20 - 11:00 O-16		Godefridus Peters, Amsterdam University Medical Centers The Netherlands Metabolism as a target for drug development
11:00–11:30		Shimadzu Coffee break + poster presentations

Chair: Christos Reppas
11:30 - 12:10 O-17		Kin Tam, University of Macau, China Dichloroacetophenone derivatives as pyruvate dehydrogenase kinase inhibitor in non-small cell lung cancer models
12:10 - 12:40 O-18		Andrej Perdih, National Institute of Chemistry, Ljubljana, Slovenia Development of catalytic inhibitors of topoisomerase IIα as chemotherapeutic agents
12:40 - 13:10 O-19		Sandra Cvijić, University of Belgrade, Serbia Highlight on the benefits of PBPK modeling: A link between drug properties and it's in vivo performance
13:10 - 13:40 O-20		Ines Nikolić, University of Belgrade, Serbia Navigating Towards Improved Cytotoxicity Assessment in Nanomedicine Development: Shifting from Colorimetric to Fluorescence-Based Assays
13:40 - 13:55 SP-01		Luka Mihajlović, Analysis d.o.o., Belgrade, Serbia High-resolution mass spectrometry in drug discovery and design – trends and perspectivesd
13:55 - 14:10 SP-02		Stefan Jovanović, Shimadzu Coorporation, Serbia Determination of active components in medicines and food on Shimadzu chromatographies
14:10 - 14:25 SP-03		Nebojša Jankov, PrimeVigilance Ltd, Belgrade, Serbia Advancing drug safety: PrimeVigilance's comprehensive pharmacovigilance approach
14:25 - 14:40		Brief Exchange with Nenad M. Kostić
15:00 - 23:00		Excursion to Viminacium (Roman City and Legionary Fort) with Conference dinner

Wednesday, September 6

Special Session on the ADME properties and toxicity prediction by HPLC
Chair: Klara Valko

19:00 - 19:40 O-21		Laurence Philippe-Venec, PIC Analytics, USA Chromatography to highlight compounds behavior in a membrane: a journey of interactions
19:40 - 10:20 O-22		Giulia Caron, University of Turin, Italy The love story of physchem data and oral bioavailable bRo5 drug candidates
10:20 - 10:50 O-23		Krzesimir Ciura, Medical University of Gdańsk, Poland Combining biomimetic chromatography and the Quantitative Structure-(Chromatographic) Retention Relationships approach using machine learning
10:50 - 11:20		PrimeVigilance Coffee break + poster presentations

Chair: Krzesimir Ciura
11:20 - 12:00 O-24		Klara Valko, Biomimetic chromatography, UK Application of lipophilicity, protein and phospholipid binding measured by HPLC for prediction of ADME properties and toxicity of compounds
12:00 - 12:30 O-25		Chrysanthos Stergiopoulos, University of Athens, Greece Application of biomimetic chromatography for the prediction of acute aquatic toxicity of organic pollutants
12:30 - 13:00 O-26		Giacomo Russo, Edinburgh University, Scotland From delta logKwIAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring?
13:00 - 13:30 O-27		Marti Roses, University of Barcelona, Spain Ability of physicochemical systems to predict skin permeation of neutral compounds. A comparison study
13:30 - 14:00		Open discussions about the future of the chromatographic techniques for the physicochemical characterization of compounds and prediction of their fate in vivo and in the environment
14:00 - 15:30		Lunch break
Chair: Kin Tam
15:30 - 16:00 O-28		Martin Kuentz, Univ. of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland Towards better understanding of drug interactions with mesoporous silica carriers by using inverse gas chromatography and molecular modelling
16:00 - 16:30 O-29		Mire Zloh, UCL School of Pharmacy, UK In silico approaches for understanding the role of intermolecular interactions in formulations and combination therapies: implications for ADME properties optimization
16:30 - 17:00 O-30		Uko Maran, University of Tartu, Estonia Octanol-water distribution coefficient (logD) as molecular descriptor to count environmental effect in QSAR models: comparison on experimental and predicted values for common reference drug substances for wide pH scale
17:00 - 17:30 O-31		Robert Vianello, Rudjer Boskovic Institute, Zagreb, Croatia With a little help from computer-aided drug design – new antitumor agents as tubulin polymerization inhibitors
17:30 - 18:00		Coffee break + poster presentations
Chair: Mire Zloh
18:00 - 18:30 O-32		Slavica Erić, University of Belgrade, Serbia Elucidation of molecular mechanisms of activity of Echinacea spp. constituents for possible treatment of COVID 19 by computer-aided methods
18:30 - 18:50 O-33		Selma Zukić, University of Tartu, Estonia Quantitative structure-activity relationship of pyrimidine and uracil derivatives for characterization and evaluation the potential of chemical compounds for cervical cancer
18:50 - 19:20 O-34		Jelena Đuriš, University of Belgrade, Serbia Bridging science & regulation: quality by design in patient-focused formulation development
19:20 - 19:50 O-35		Milena Čukić Radenković, Empa Swiss Federal Laboratories for Materials Science and Technology, Switzerland Improvement of Digital twin for transdermal fentanyl delivery based on anomalous diffusion
19:50 - 20:10		Closing ceremony
20:30 - 23:00		Farewell dinner (optional)