Scope

 
The scope of the conference includes but is not limited to the following topics:

1.    Advances in methods and instrumentation in the physico-chemical / activity profiling of drug substances:
- Ionization, solubility, lipophilicity, permeability
- Methods for the determination of physico-chemical properties of drugs: potentiometry, spectroscopy, chromatography etc.
- Lead optimization
- High throughput screening
 
2.    Polymorphism, synthesis and characterization of different solid forms, hydrates and solvates:
- Thermal methods (TG, DSC, microcalorimetry and combined techniques)
- Solid state NMR
- X-ray diffraction (XRD)
- Spectral techniques (FTIR, Raman, NIR)
- DVS (dynamic vapour sorption)
- Counterfeit detection
 
3.    ADME and DMPK
- The importance of ADME tests for preclinical development
- In vitro ADME testing (metabolism, permeabity, transporters, protein binding, reaction phenotyping, enzyme inhibition, etc.)
- Transporters and permeability
- Metabolite identification and profiling
- Changing trends in use of hepatocytes and microsomes for metabolism studies in drug discovery
- Challenges in the research in neurodegenerative deseases and mechanisms
- Challenges in the research in tyrosine kinase inhibitors as anticancer agents
- ADME/PK modelling
- Optimization of ADME properties in drug design and screening
- Bioavailability and DMPK
- Instrumental methods in ADME/DMPK
- ADME and metabonomics
- High throughput ADME methods
 
4.    Biomolecular interactions and analytical techniques of importance in medicinal chemistry and pharma research:
- Molecular interactions and receptor bindings
- Drug-drug interaction studies
- Protein binding assays
- Molecular imaging
- Chiral Blancpain Replica separations
- Process analytical technologies
- Metabolic profiling
- Analysis of biomolecules, proteins, carbohydrates
- Protein and nucleic acids sequencing and dynamics
- Genomics, proteomics and metabolomics
 
5.    Computational methods and modelling in drug discovery:
- QSAR
- In silico screening and molecular modelling
- Bioinformatics and cheminformatics
6.    Preclinical studies, drug rolex replica watches development and regulatory affairs:
- Pharmacodynamics
- Toxicology and genotoxicity
- Animal tests and in vitro assays
- PK/PD modeling
- Formulations and delivery systems
- Clinical trials
- Regulatory requirements and policy
- Companion diagnostic device
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