Program

 

Friday, September 20th
09:00 – 10:00
Participant registration, Conference Hall, Hotel Princess Royal
10:00 – 10:15
Summer school opening
10:15 – 13:00
Mario Grassi, Trieste University, Italy, Determination of nanocrystals size distribution in polymer-drug systems
  Lunch
15:00 – 16.50
John Comer, Sirius Analytical Ltd., UK, Overview of physicochemical profiling. Biopharmaceutical Classification System (BCS), ionization (pKa), lipophilicity (logP), and solubility (S0, Sw, Sbuf). Effects of pH.
16:50 - 17:15 Cofffe break
17:15 - 19:00
Alex Avdeef, in-ADME Research, USA, Salt Solubility and Solubility Product (Ksp) measurement -new perspectives in support of salt selection
 
 
Saturday, September 21st
09:00 – 10:45
Sven Frokjaer, University of Copenhage, Denmark, Formulation Development of Peptides and Proteins
10:45 - 11:15 Coffee break
11:15 – 13:00
Biserka Cetina Čižmek, Pliva Ltd, Croatia, Analytical methodologies in the formulation development
  Lunch
15:00 – 16.45
Alex Avdeef, in-ADME Research, USA, Drug inestinal absorption and permeability. Artifical membrane (PAMPA) and cell-based models (Caco-2/MDCK) - effects of pH. Passive property prediction.
16:45 - 17:15 Cofffe break
17:15 – 18:00
Alex Avdeef, in-ADME Research, USA, Blood-brain barrier (BBB) penetration and permeability. IVIV correlations between in vitro brain microcapillary endothelial cell (BMEC) models and rodent in situ brain perfusion drug uptake. Artifical membrane (PAMPA-BBB). A novel in silico brain penetration classification (BPC) prediction model.
18:10 – 19:00 Biserka Cetina Čižmek, Pliva Ltd, Croatia, Excipients and their compatibility
 
 
 
Sunday, September 22nd
09:00 – 10:45
Rolf Hilfiker, Solvias AG, Switzerland, Co-Crystals: The importance of choosing the optimal solid form of drug. Salts, co-crystals, polymorphs and solvates. Part 1.
10:45 - 11:15 Coffee break
11:15 – 13:00
Rolf Hilfiker, Solvias AG, Switzerland, Co-Crystals: The importance of choosing the optimal solid form of drug. Salts, co-crystals, polymorphs and solvates. Part 2.
  Lunch
15:00 – 16.45
Christos Reppas, National and Kapodistrian Collaborators of Athens, Greece, Choosing the optimal oral dosage form.
16:45 - 17:15 Cofffe break
17:15 – 19:00
Christos Reppas, National and Kapodistrian Collaborators of Athens, Greece, In vitro performance testing of orally administred drug products: Case studies.
20:00 –
Welcome party, joint ESSFD-1 and PCMDDD-3 event, Taraca Lounge bar
 
 
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